pentobarbital will minimize the extent or effect of doxorubicin by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.pentobarbital will reduce the extent or result of celecoxib by influencing hepatic enzyme CYP2C9/ten metabolism. Slight/Significance Unfamiliar.pentobarbital will lower the level or influence of colchicine by a